منابع مشابه
Role for ATM in DNA damage-induced phosphorylation of BRCA1.
The human genetic disorder ataxia-telangiectasia is characterized by immunodeficiency, progressive cerebellar ataxia, radiosensitivity, cell cycle checkpoint defects, and cancer predisposition. The gene product [ataxia-telangiectasia mutation (ATM)] mutated in this syndrome is a component of the DNA damage detection pathway. Loss of ATM function in human and mouse cells causes defects in DNA re...
متن کاملWip1 and ATM in tumor evolution: role for BRCA1
Sequential accumulation of mutations is a central event that drives the conversion of normal cells into cancer. The recent advent of whole-genome sequencing data highlighted the existence of several hundred to thousand’s of mutations in tumors affecting the integrity of the genome. In order to maintain genomic stability, and thus to suppress tumorigenesis, eukaryotic cells have evolved several ...
متن کاملATM phosphorylates histone H2AX in response to DNA double-strand breaks.
A very early step in the response of mammalian cells to DNA double-strand breaks is the phosphorylation of histone H2AX at serine 139 at the sites of DNA damage. Although the phosphatidylinositol 3-kinases, DNA-PK (DNA-dependent protein kinase), ATM (ataxia telangiectasia mutated), and ATR (ATM and Rad3-related), have all been implicated in H2AX phosphorylation, the specific kinase involved has...
متن کاملFunctional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress.
The BRCA1 gene encodes a tumor suppressor that is mutated in 50% of familial breast cancers. The BRCA1 protein has been implicated in the DNA damage response, as DNA damage induces the phosphorylation of BRCA1 and causes its recruitment into nuclear foci that contain DNA repair proteins. The ataxia-telangiectasia-mutated (ATM) gene product controls overall BRCA1 phosphorylation in response to g...
متن کاملImpaired skin and mammary gland development and increased gamma-irradiation-induced tumorigenesis in mice carrying a mutation of S1152-ATM phosphorylation site in Brca1.
The tumor suppressor BRCA1 interacts with many proteins and undergoes multiple modifications on DNA damage. ATM, a key molecule of the DNA damage response, phosphorylates S1189 of BRCA1 after gamma-irradiation. S1189 of BRCA1 is known as a unique ATM phosphorylation site in BRCA1 exon 11. To study the functions of ATM-dependent phosphorylation of BRCA1-S1189, we generated a mouse model carrying...
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ژورنال
عنوان ژورنال: Breast Cancer Research
سال: 1999
ISSN: 1465-542X
DOI: 10.1186/bcr-1999-66641